PT-141

What is PT-141 (bremelanotide) and how does it work?

PT-141 is a libido-boosting peptide. It’s a synthetic peptide analog of alpha-MSH, which is a neurohormone in the melanocortin system. It works by activating the MC3R and MC4R receptors in the brain. Intranasal use of this peptide causes erection in many animals and humans. However, PT-141 doesn’t cause the drop in blood pressure, unlike current erectile drugs, suggesting that it doesn’t work through the cardiovascular system.

The melanocortin system controls metabolism and appetite, along with heart health, stress response, and sexual function. Alpha-melanocyte stimulating hormone (alpha-MSH) can modulate the nervous and immune systems. It also has anti-inflammatory and anti-microbial activities.

In the skin, alpha-MSH also influences skin darkness. However, unlike melanotan 2, PT-141 does not cause skin darkening.